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GNMT Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q14749 |
|---|---|
| Clone Names | 100617101 |
| Gene ID | 27232 |
|---|---|
| Other Names | Glycine N-methyltransferase, GNMT |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | GNMT (HGNC:4415) |
|---|---|
| Function | Catalyzes the methylation of glycine by using S- adenosylmethionine (AdoMet) to form N-methylglycine (sarcosine) with the concomitant production of S-adenosylhomocysteine (AdoHcy), a reaction regulated by the binding of 5-methyltetrahydrofolate. Plays an important role in the regulation of methyl group metabolism by regulating the ratio between S-adenosyl-L-methionine and S-adenosyl-L- homocysteine. |
| Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:P13255}. |
| Tissue Location | Expressed only in liver, pancreas, and prostate. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is an enzyme thatcatalyzes the conversion of S-adenosyl-L-methionine (along withglycine) to S-adenosyl-L-homocysteine and sarcosine. The encodedprotein is found in the cytoplasm and acts as a homotetramer.Defects in this gene are a cause of GNMT deficiency(hypermethioninemia).
References
Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :Lee, C.M., et al. Gene 443 (1-2), 151-157 (2009) :Boyles, A.L., et al. Genet. Epidemiol. 33(3):247-255(2009)Yen, C.H., et al. Toxicol. Appl. Pharmacol. 235(3):296-304(2009)Franke, B., et al. Birth Defects Res. Part A Clin. Mol. Teratol. 85(3):216-226(2009)
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