|Other Names||Glycine N-methyltransferase, GNMT|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the methylation of glycine by using S- adenosylmethionine (AdoMet) to form N-methylglycine (sarcosine) with the concomitant production of S-adenosylhomocysteine (AdoHcy). Possible crucial role in the regulation of tissue concentration of AdoMet and of metabolism of methionine.|
|Tissue Location||Abundant in liver.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is an enzyme thatcatalyzes the conversion of S-adenosyl-L-methionine (along withglycine) to S-adenosyl-L-homocysteine and sarcosine. The encodedprotein is found in the cytoplasm and acts as a homotetramer.Defects in this gene are a cause of GNMT deficiency(hypermethioninemia).
Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :Lee, C.M., et al. Gene 443 (1-2), 151-157 (2009) :Boyles, A.L., et al. Genet. Epidemiol. 33(3):247-255(2009)Yen, C.H., et al. Toxicol. Appl. Pharmacol. 235(3):296-304(2009)Franke, B., et al. Birth Defects Res. Part A Clin. Mol. Teratol. 85(3):216-226(2009)
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