ASB7 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q9H672 |
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Clone Names | 110726013 |
Gene ID | 140460 |
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Other Names | Ankyrin repeat and SOCS box protein 7, ASB-7, ASB7 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | ASB7 |
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Function | Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene belongs to a family ofankyrin repeat proteins that, along with four other proteinfamilies, contains a C-terminal SOCS box motif. Growing evidencesuggests that the SOCS box acts as a bridge between specificsubstrate-binding domains and the more generic proteins thatcomprise a large family of E3 ubiquitin protein ligases. In thisway, SOCS box containing proteins may regulate protein turnover bytargeting proteins for polyubiquination and, therefore, forproteasome-mediated degradation. Two alternative transcriptsencoding different isoforms have been described. [provided byRefSeq].
References
Lamesch, P., et al. Genomics 89(3):307-315(2007)Fu, G.K., et al. Genomics 84(1):205-210(2004)Kile, B.T., et al. Trends Biochem. Sci. 27(5):235-241(2002)
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