|Other Names||Ankyrin repeat and SOCS box protein 7, ASB-7, ASB7|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene belongs to a family ofankyrin repeat proteins that, along with four other proteinfamilies, contains a C-terminal SOCS box motif. Growing evidencesuggests that the SOCS box acts as a bridge between specificsubstrate-binding domains and the more generic proteins thatcomprise a large family of E3 ubiquitin protein ligases. In thisway, SOCS box containing proteins may regulate protein turnover bytargeting proteins for polyubiquination and, therefore, forproteasome-mediated degradation. Two alternative transcriptsencoding different isoforms have been described. [provided byRefSeq].
Lamesch, P., et al. Genomics 89(3):307-315(2007)Fu, G.K., et al. Genomics 84(1):205-210(2004)Kile, B.T., et al. Trends Biochem. Sci. 27(5):235-241(2002)
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