|Other Names||Nephronectin, Preosteoblast EGF-like repeat protein with MAM domain, Protein EGFL6-like, NPNT, EGFL6L, POEM|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Functional ligand of integrin alpha-8/beta-1 in kidney development. Regulates the expression of GDNF with integrin alpha- 8/beta-1 which is essential for kidney development. May also play a role in the development and function of various tissues, regulating cell adhesion, spreading and survival through the binding of several integrins (By similarity).|
|Cellular Location||Secreted, extracellular space, extracellular matrix. Note=Trapped on the cell surface or in the extracellular matrix.|
|Tissue Location||Expressed in kidney and lung and to a lower extent in brain, pregnant uterus, placenta, thyroid gland and blood vessels.|
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Functional ligand of integrin alpha-8/beta-1 in kidney development. Regulates the expression of GDNF with integrin alpha-8/beta-1 which is essential for kidney development. May also play a role in the development and function of various tissues, regulating cell adhesion, spreading and survival through the binding of several integrins (By similarity).
Kalsi, G., et al. Hum. Mol. Genet. 19(12):2497-2506(2010)Hancock, D.B., et al. Nat. Genet. 42(1):45-52(2010)Kahai, S., et al. PLoS ONE 4 (10), E7535 (2009) :Huang, J.T., et al. Int. J. Mol. Med. 15(4):719-724(2005)Brandenberger, R., et al. J. Cell Biol. 154(2):447-458(2001)
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