|Other Names||Spindle assembly abnormal protein 6 homolog, HsSAS-6, SASS6, SAS6|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Central scaffolding component of the centrioles ensuring their 9-fold symmetry. Required for centrosome biogenesis and duplication: required both for mother-centriole-dependent centriole duplication and deuterosome-dependent centriole amplification in multiciliated cells. Overexpression results in excess foci-bearing centriolar markers.|
|Cellular Location||Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole Note=Component of the deuterosome, a structure that promotes de novo centriole amplification in multiciliated cells that can generate more than 100 centrioles (By similarity). Component of the centrosome. Associated only transiently with nascent procentrioles during centriole biogenesis.|
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Provided below are standard protocols that you may find useful for product applications.
SAS6 is necessary for centrosome duplication and functionsduring procentriole formation; SAS6 functions to ensure that eachcentriole seeds the formation of a single procentriole per cellcycle Strnad et al., (2007) [PubMed 17681132].
Tang, C.J., et al. Nat. Cell Biol. 11(7):825-831(2009)Strnad, P., et al. Dev. Cell 13(2):203-213(2007)Kleylein-Sohn, J., et al. Dev. Cell 13(2):190-202(2007)Habedanck, R., et al. Nat. Cell Biol. 7(11):1140-1146(2005)Leidel, S., et al. Nat. Cell Biol. 7(2):115-125(2005)
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