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SASS6 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q6UVJ0 |
|---|---|
| Clone Names | 110729203 |
| Gene ID | 163786 |
|---|---|
| Other Names | Spindle assembly abnormal protein 6 homolog, HsSAS-6, SASS6, SAS6 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | SASS6 (HGNC:25403) |
|---|---|
| Synonyms | SAS6 |
| Function | Central scaffolding component of the centrioles ensuring their 9-fold symmetry. Required for centrosome biogenesis and duplication: required both for mother-centriole-dependent centriole duplication and deuterosome-dependent centriole amplification in multiciliated cells. Overexpression results in excess foci-bearing centriolar markers. Required for the recruitment of STIL to the procentriole and for STIL-mediated centriole amplification (PubMed:22020124). |
| Cellular Location | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Component of the deuterosome, a structure that promotes de novo centriole amplification in multiciliated cells that can generate more than 100 centrioles (By similarity). Component of the centrosome. Associated only transiently with nascent procentrioles during centriole biogenesis {ECO:0000250|UniProtKB:Q80UK7} |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
SAS6 is necessary for centrosome duplication and functionsduring procentriole formation; SAS6 functions to ensure that eachcentriole seeds the formation of a single procentriole per cellcycle Strnad et al., (2007) [PubMed 17681132].
References
Tang, C.J., et al. Nat. Cell Biol. 11(7):825-831(2009)Strnad, P., et al. Dev. Cell 13(2):203-213(2007)Kleylein-Sohn, J., et al. Dev. Cell 13(2):190-202(2007)Habedanck, R., et al. Nat. Cell Biol. 7(11):1140-1146(2005)Leidel, S., et al. Nat. Cell Biol. 7(2):115-125(2005)
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