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FNDC4 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9H6D8 |
|---|---|
| Clone Names | 110811078 |
| Gene ID | 64838 |
|---|---|
| Other Names | Fibronectin type III domain-containing protein 4, Fibronectin type III repeat-containing protein 1, FNDC4, FRCP1 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | FNDC4 |
|---|---|
| Synonyms | FRCP1 |
| Function | Acts as an anti-inflammatory factor in the intestine and colon. Binds to and acts on macrophages to down-regulate pro- inflammatory gene expression. Affects key macrophage functions, including phagocytosis, by down-regulating many key pathways for macrophage activation, partly via by STAT3 activation and signaling. May be required to dampen the immunological response in colitis. |
| Cellular Location | Membrane; Single-pass type I membrane protein. Secreted {ECO:0000250|UniProtKB:Q3TR08}. Note=The N-terminus is probably cleaved to release a secreted extracellular portion of the protein {ECO:0000250|UniProtKB:Q3TR08} |
| Tissue Location | Up-regulated in colon cells of patients with inflammatory bowel disease (IBD). |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
FNDC4 contains a fibronectin type-III (FN3) domain. FN3 repeats have been found in various protein families including extracellular-matrix molecules, cell-surface receptors, enzymes, and muscle proteins. The function of FNDC4 is unknown.
References
O'Seaghdha, C.M., et al. Hum. Mol. Genet. 19(21):4296-4303(2010)Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Kottgen, A., et al. Nat. Genet. 42(5):376-384(2010)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Hillier, L.W., et al. Nature 434(7034):724-731(2005)
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