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MND1 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9BWT6 |
|---|---|
| Clone Names | 110811126 |
| Gene ID | 84057 |
|---|---|
| Other Names | Meiotic nuclear division protein 1 homolog, MND1 {ECO:0000312|EMBL:EAX049641} |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | MND1 {ECO:0000312|EMBL:EAX04964.1} |
|---|---|
| Function | Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis (By similarity). Stimulates both DMC1- and RAD51-mediated homologous strand assimilation, which is required for the resolution of meiotic double- strand breaks. |
| Cellular Location | Nucleus. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The product of the MND1 gene associates with HOP2 (MIM608665) to form a stable heterodimeric complex that binds DNA andstimulates the recombinase activity of RAD51 (MIM 179617) and DMC1(MIM 602721) (Chi et al., 2007 [PubMed 17639080]). Both the MND1and HOP2 genes are indispensable for meioticrecombination.
References
Rose, J. Phd, et al. Mol. Med. (2010) In press :Chi, P., et al. Genes Dev. 21(14):1747-1757(2007)Enomoto, R., et al. J. Biol. Chem. 281(9):5575-5581(2006)Tsubouchi, H., et al. Mol. Cell. Biol. 22(9):3078-3088(2002)
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