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MRGBP Antibody (Center) Blocking Peptide

Synthetic peptide

     
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  • CITATIONS
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Product Information
Primary Accession Q9NV56
Clone Names 110811128
Peptide ID 110811128
Additional Information
Gene ID 55257
Other Names MRG/MORF4L-binding protein, MRG-binding protein, Up-regulated in colon cancer 4, Urcc4, MRGBP, C20orf20
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name MRGBP
Synonyms C20orf20
Function Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage.
Cellular Location Nucleus.
Research Areas
Citations (0)

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Background

Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome -DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage.

References

Yamaguchi, K., et al. Br. J. Cancer 102(2):325-331(2010)Cai, Y., et al. J. Biol. Chem. 280(14):13665-13670(2005)Cai, Y., et al. J. Biol. Chem. 278(44):42733-42736(2003)Deloukas, P., et al. Nature 414(6866):865-871(2001)

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$ 80.00
Cat# BP18098c
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