|Other Names||Membrane-spanning 4-domains subfamily A member 12, MS4A12|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May be involved in signal transduction as a component of a multimeric receptor complex.|
|Cellular Location||Membrane; Multi-pass membrane protein.|
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The protein encoded by this gene is a cell surface proteinfound primarily in the apical membrane of colonocytes. Silencing ofthis gene in colon cancer cells inhibits the proliferation, cellmotility, and chemotactic invasion of cells. This gene is part of acluster of similar genes found on chromosome 11. Two transcriptvariants encoding different isoforms have been found for this gene.
Koslowski, M., et al. Mol. Cancer 8, 77 (2009) :Koslowski, M., et al. Cancer Res. 68(9):3458-3466(2008)Lamesch, P., et al. Genomics 89(3):307-315(2007)Liang, Y., et al. Immunogenetics 53(5):357-368(2001)Liang, Y., et al. Genomics 72(2):119-127(2001)
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