N6AMT1 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q9Y5N5 |
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Clone Names | 110811137 |
Gene ID | 29104 |
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Other Names | HemK methyltransferase family member 2, 211-, MHsaHemK2P, N(6)-adenine-specific DNA methyltransferase 1, N6AMT1, C21orf127, HEMK2 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | N6AMT1 {ECO:0000303|PubMed:30017583, ECO:0000312|HGNC:HGNC:16021} |
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Function | Methyltransferase that can methylate proteins and, to a lower extent, arsenic (PubMed:18539146, PubMed:21193388, PubMed:30017583, PubMed:31636962, PubMed:31061526). Catalytic subunit of a heterodimer with TRMT112, which monomethylates 'Lys-12' of histone H4 (H4K12me1), a modification present at the promoters of numerous genes encoding cell cycle regulators (PubMed:31061526). Catalytic subunit of a heterodimer with TRMT112, which catalyzes N5-methylation of Glu residue of proteins with a Gly-Gln-Xaa-Xaa-Xaa-Arg motif (PubMed:18539146, PubMed:31632689, PubMed:31636962). Methylates ETF1 on 'Gln-185'; ETF1 needs to be complexed to ERF3 in its GTP-bound form to be efficiently methylated (PubMed:18539146, PubMed:20606008, PubMed:31636962, PubMed:31061526). May also play a role in the modulation of arsenic-induced toxicity by mediating the conversion of monomethylarsonous acid (3+) into the less toxic dimethylarsonic acid (PubMed:21193388, PubMed:25997655). It however only plays a limited role in arsenic metabolism compared with AS3MT (PubMed:25997655). |
Cellular Location | Nucleus {ECO:0000250|UniProtKB:Q6SKR2}. |
Tissue Location | Widely expressed, with highest expression in parathyroid and pituitary glands, followed by adrenal gland and kidney, and lowest expression in leukocytes and mammary gland |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene belongs to themethyltransferase superfamily. Alternative splicing occurs at thislocus and two transcript variants encoding distinct isoforms havebeen identified.
References
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Figaro, S., et al. FEBS Lett. 582(16):2352-2356(2008)Seshadri, S., et al. BMC Med. Genet. 8 SUPPL 1, S15 (2007) :Hwang, S.J., et al. BMC Med. Genet. 8 SUPPL 1, S10 (2007) :
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