|Other Names||HemK methyltransferase family member 2, 211-, MHsaHemK2P, N(6)-adenine-specific DNA methyltransferase 1, N6AMT1, C21orf127, HEMK2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Heterodimeric methyltransferase that catalyzes N5- methylation of ETF1 on 'Gln-185', using S-adenosyl L-methionine as methyl donor. ETF1 needs to be complexed to ERF3 in its GTP-bound form to be efficiently methylated. May play a role in the modulation of arsenic-induced toxicity. May be involved in the conversion of monomethylarsonous acid (3+) into the less toxic dimethylarsonic acid.|
|Tissue Location||Widely expressed, with highest expression in parathyroid and pituitary glands, followed by adrenal gland and kidney, and lowest expression in leukocytes and mammary gland|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene belongs to themethyltransferase superfamily. Alternative splicing occurs at thislocus and two transcript variants encoding distinct isoforms havebeen identified.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Figaro, S., et al. FEBS Lett. 582(16):2352-2356(2008)Seshadri, S., et al. BMC Med. Genet. 8 SUPPL 1, S15 (2007) :Hwang, S.J., et al. BMC Med. Genet. 8 SUPPL 1, S10 (2007) :
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