MYH9 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P35579 |
---|---|
Clone Names | 110729013 |
Gene ID | 4627 |
---|---|
Other Names | Myosin-9, Cellular myosin heavy chain, type A, Myosin heavy chain 9, Myosin heavy chain, non-muscle IIa, Non-muscle myosin heavy chain A, NMMHC-A, Non-muscle myosin heavy chain IIa, NMMHC II-a, NMMHC-IIA, MYH9 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | MYH9 |
---|---|
Function | Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Required for cortical actin clearance prior to oocyte exocytosis (By similarity). Promotes cell motility in conjunction with S100A4 (PubMed:16707441). During cell spreading, plays an important role in cytoskeleton reorganization, focal contact formation (in the margins but not the central part of spreading cells), and lamellipodial retraction; this function is mechanically antagonized by MYH10 (PubMed:20052411). |
Cellular Location | Cytoplasm, cytoskeleton. Cytoplasm, cell cortex {ECO:0000250|UniProtKB:Q8VDD5}. Cytoplasmic vesicle, secretory vesicle, Cortical granule {ECO:0000250|UniProtKB:Q8VDD5}. Note=Colocalizes with actin filaments at lamellipodia margins and at the leading edge of migrating cells (PubMed:20052411). In retinal pigment epithelial cells, predominantly localized to stress fiber-like structures with some localization to cytoplasmic puncta (PubMed:27331610) |
Tissue Location | In the kidney, expressed in the glomeruli. Also expressed in leukocytes. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a myosin IIA heavy chain that containsan IQ domain and a myosin head-like domain. The protein is involvedin several important functions, including cytokinesis, cellmotility and maintenance of cell shape. Defects in MYH9 are thecause of non-syndromic sensorineural deafness autosomal dominanttype 17, Epstein syndrome, Alport syndrome withmacrothrombocytopenia, Sebastian syndrome, Fechtner syndrome andmacrothrombocytopenia with progressive sensorineural deafness.
References
Arii, J., et al. Nature 467(7317):859-862(2010)Genovese, G., et al. Kidney Int. 78(7):698-704(2010)Tzur, S., et al. Hum. Genet. 128(3):345-350(2010)Bostrom, M.A., et al. Hum. Genet. 128(2):195-204(2010)Oleksyk, T.K., et al. PLoS ONE 5 (7), E11474 (2010) :
If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abcepta.com.