|Other Names||Dentin sialophosphoprotein, Dentin phosphoprotein, Dentin phosphophoryn, DPP, Dentin sialoprotein, DSP, DSPP|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||DSP may be an important factor in dentinogenesis. DPP may bind high amount of calcium and facilitate initial mineralization of dentin matrix collagen as well as regulate the size and shape of the crystals.|
|Cellular Location||Secreted, extracellular space, extracellular matrix|
|Tissue Location||Expressed in teeth. DPP is synthesized by odontoblast and transiently expressed by pre-ameloblasts|
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This gene encodes two principal proteins of the dentinextracellular matrix of the tooth. The preproprotein is secreted byodontoblasts and cleaved into dentin sialoprotein and dentinphosphoprotein. Dentin phosphoprotein is thought to be involved inthe biomineralization process of dentin. Mutations in this genehave been associated with dentinogenesis imperfecta-1; in someindividuals, dentinogenesis imperfecta occurs in combination withan autosomal dominant form of deafness. Allelic differences due torepeat polymorphisms have been found for this gene. [provided byRefSeq].
Joslyn, G., et al. Alcohol. Clin. Exp. Res. 34(5):800-812(2010)Bai, H., et al. BMC Med. Genet. 11, 23 (2010) :Kida, M., et al. Eur. J. Oral Sci. 117(6):691-694(2009)Wheeler, H.E., et al. PLoS Genet. 5 (10), E1000685 (2009) :Qu, E.J., et al. Zhonghua Yi Xue Yi Chuan Xue Za Zhi 26(5):536-538(2009)
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