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GTF2I Antibody (N-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession P78347
Clone Names 90121140
Additional Information
Gene ID 2969
Other Names General transcription factor II-I, GTFII-I, TFII-I, Bruton tyrosine kinase-associated protein 135, BAP-135, BTK-associated protein 135, SRF-Phox1-interacting protein, SPIN, Williams-Beuren syndrome chromosomal region 6 protein, GTF2I, BAP135, WBSCR6
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name GTF2I
Synonyms BAP135, WBSCR6
Function Interacts with the basal transcription machinery by coordinating the formation of a multiprotein complex at the C-FOS promoter, and linking specific signal responsive activator complexes. Promotes the formation of stable high-order complexes of SRF and PHOX1 and interacts cooperatively with PHOX1 to promote serum-inducible transcription of a reporter gene deriven by the C-FOS serum response element (SRE). Acts as a coregulator for USF1 by binding independently two promoter elements, a pyrimidine-rich initiator (Inr) and an upstream E-box. Required for the formation of functional ARID3A DNA- binding complexes and for activation of immunoglobulin heavy-chain transcription upon B-lymphocyte activation.
Cellular Location Cytoplasm. Nucleus {ECO:0000255|PROSITE-ProRule:PRU00484, ECO:0000269|PubMed:10373551} Note=Colocalizes with BTK in the cytoplasm
Tissue Location Ubiquitous. Isoform 1 is strongly expressed in fetal brain, weakly in adult brain, muscle, and lymphoblasts and is almost undetectable in other adult tissues, while the other isoforms are equally expressed in all adult tissues
Research Areas
Citations (0)
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Background

This gene encodes a multifunctional phosphoprotein withroles in transcription and signal transduction. It is deleted inWilliams-Beuren syndrome, a multisystem developmental disordercaused by the deletion of contiguous genes at chromosome 7q11.23.Alternative splicing results in multiple transcript variants.Related pseudogenes have been identified on chromosomes 7, 13 and21.

References

Antonell, A., et al. J. Med. Genet. 47(5):312-320(2010)Lazebnik, M.B., et al. J. Biol. Chem. 284(52):36234-36239(2009)Sacristan, C., et al. Eur. J. Immunol. 39(9):2584-2595(2009)Makeyev, A.V., et al. Gene 433 (1-2), 16-25 (2009) :Olsen, J.V., et al. Cell 127(3):635-648(2006)

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$ 277.78
Cat# BP18119a
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