|Other Names||Gamma-enolase, 2-phospho-D-glycerate hydro-lyase, Enolase 2, Neural enolase, Neuron-specific enolase, NSE, ENO2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Has neurotrophic and neuroprotective properties on a broad spectrum of central nervous system (CNS) neurons. Binds, in a calcium-dependent manner, to cultured neocortical neurons and promotes cell survival (By similarity).|
|Cellular Location||Cytoplasm. Cell membrane. Note=Can translocate to the plasma membrane in either the homodimeric (alpha/alpha) or heterodimeric (alpha/gamma) form.|
|Tissue Location||The alpha/alpha homodimer is expressed in embryo and in most adult tissues. The alpha/beta heterodimer and the beta/beta homodimer are found in striated muscle, and the alpha/gamma heterodimer and the gamma/gamma homodimer in neurons|
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This gene encodes one of the three enolase isoenzymesfound in mammals. This isoenzyme, a homodimer, is found in matureneurons and cells of neuronal origin. A switch from alpha enolaseto gamma enolase occurs in neural tissue during development in ratsand primates.
Martins-de-Souza, D., et al. J Psychiatr Res 44(14):989-991(2010)Mukhtarova, S.N. Georgian Med News 181, 49-54 (2010) :Planche, V., et al. Ann. Biol. Clin. (Paris) 68(2):239-242(2010)Chaves, M.L., et al. J Neuroinflammation 7, 6 (2010) :Wijeyaratne, S.M., et al. Eur J Vasc Endovasc Surg 38(3):262-266(2009)
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