MOG Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q16653 |
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Clone Names | 90415109 |
Gene ID | 4340 |
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Other Names | Myelin-oligodendrocyte glycoprotein, MOG |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | MOG |
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Function | Mediates homophilic cell-cell adhesion (By similarity). Minor component of the myelin sheath. May be involved in completion and/or maintenance of the myelin sheath and in cell-cell communication. |
Cellular Location | [Isoform 1]: Cell membrane; Multi- pass membrane protein [Isoform 2]: Cell membrane; Single- pass type I membrane protein [Isoform 4]: Cell membrane; Single- pass type I membrane protein [Isoform 7]: Cell membrane; Single- pass type I membrane protein [Isoform 9]: Cell membrane; Single- pass type I membrane protein |
Tissue Location | Found exclusively in the CNS, where it is localized on the surface of myelin and oligodendrocyte cytoplasmic membranes |
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Provided below are standard protocols that you may find useful for product applications.
Background
The product of this gene is a membrane protein expressedon the oligodendrocyte cell surface and the outermost surface ofmyelin sheaths. Due to this localization, it is a primary targetantigen involved in immune-mediated demyelination. This protein maybe involved in completion and maintenance of the myelin sheath andin cell-cell communication. Alternatively spliced transcriptvariants encoding different isoforms have been identified.
References
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Boyle, L.H., et al. J. Neurochem. 102(6):1853-1862(2007)Allamargot, C., et al. J. Neurochem. 101(2):298-312(2007)Delarasse, C., et al. J. Neurochem. 98(6):1707-1717(2006)Ballenthin, P.A., et al. J. Neurosci. Res. 46(2):271-281(1996)
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