|Other Names||Synaptosomal-associated protein 25, SNAP-25, Super protein, SUP, Synaptosomal-associated 25 kDa protein, SNAP25, SNAP|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF.|
|Cellular Location||Cytoplasm, perinuclear region. Cell membrane; Lipid-anchor. Cell junction, synapse, synaptosome Note=Membrane association requires palmitoylation. Expressed throughout cytoplasm, concentrating at the perinuclear region (By similarity).|
|Tissue Location||Neurons of the neocortex, hippocampus, piriform cortex, anterior thalamic nuclei, pontine nuclei, and granule cells of the cerebellum|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
firstname.lastname@example.org, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Synaptic vesicle membrane docking and fusion is mediatedby SNAREs (soluble N-ethylmaleimide-sensitive factor attachmentprotein receptors) located on the vesicle membrane (v-SNAREs) andthe target membrane (t-SNAREs). The assembled v-SNARE/t-SNAREcomplex consists of a bundle of four helices, one of which issupplied by v-SNARE and the other three by t-SNARE. For t-SNAREs onthe plasma membrane, the protein syntaxin supplies one helix andthe protein encoded by this gene contributes the other two.Therefore, this gene product is a presynaptic plasma membraneprotein involved in the regulation of neurotransmitter release. Twoalternative transcript variants encoding different protein isoformshave been described for this gene.
Shimada, M., et al. Hum. Genet. 128(4):433-441(2010)Greaves, J., et al. J. Biol. Chem. 285(32):24629-24638(2010)Oner, O., et al. J Atten Disord (2010) In press :Zhang, H., et al. Eur. J. Paediatr. Neurol. (2010) In press :Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at email@example.com.