|Other Names||Serine/threonine-protein kinase SIK2, Qin-induced kinase, Salt-inducible kinase 2, SIK-2, Serine/threonine-protein kinase SNF1-like kinase 2, SIK2|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Phosphorylates 'Ser-794' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators.|
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Phosphorylates 'Ser-794' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators.
Ahmed, A.A., et al. Cancer Cell 18(2):109-121(2010)Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Nagel, S., et al. Leuk. Lymphoma 51(5):881-891(2010)Wang, A.G., et al. Biochem. Biophys. Res. Commun. 345(3):1022-1032(2006)Katoh, Y., et al. Eur. J. Biochem. 271(21):4307-4319(2004)
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