|Other Names||Mitochondrial uncoupling protein 3, UCP 3, Solute carrier family 25 member 9, UCP3, SLC25A9|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation. As a result, energy is dissipated in the form of heat. May play a role in the modulation of tissue respiratory control. Participates in thermogenesis and energy balance.|
|Cellular Location||Mitochondrion inner membrane; Multi-pass membrane protein|
|Tissue Location||Only in skeletal muscle and heart. Is more expressed in glycolytic than in oxidative skeletal muscles|
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Mitochondrial uncoupling proteins (UCP) are members of thelarger family of mitochondrial anion carrier proteins (MACP). UCPsseparate oxidative phosphorylation from ATP synthesis with energydissipated as heat, also referred to as the mitochondrial protonleak. UCPs facilitate the transfer of anions from the inner to theouter mitochondrial membrane and the return transfer of protonsfrom the outer to the inner mitochondrial membrane. They alsoreduce the mitochondrial membrane potential in mammalian cells. Thedifferent UCPs have tissue-specific expression; this gene isprimarily expressed in skeletal muscle. This gene's protein productis postulated to protect mitochondria against lipid-inducedoxidative stress. Expression levels of this gene increase whenfatty acid supplies to mitochondria exceed their oxidation capacityand the protein enables the export of fatty acids frommitochondria. UCPs contain the three solcar protein domainstypically found in MACPs. Two splice variants have been found forthis gene.
Hu, M., et al. Pharmacogenet. Genomics 20(10):634-637(2010)Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Hancock, A.M., et al. Mol. Biol. Evol. (2010) In press :Aller, R., et al. Nutr Hosp 25(4):572-576(2010)Pinheiro, A.P., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 153B (5), 1070-1080 (2010) :
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