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CCR4 Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession P51679
Clone Names 90904024
Peptide ID 90904024
Additional Information
Gene ID 1233
Other Names C-C chemokine receptor type 4, C-C CKR-4, CC-CKR-4, CCR-4, CCR4, K5-5, CD194, CCR4, CMKBR4
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name CCR4
Synonyms CMKBR4
Function High affinity receptor for the C-C type chemokines CCL17/TARC, CCL22/MDC and CKLF isoform 1/CKLF1. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates. In the CNS, could mediate hippocampal-neuron survival.
Cellular Location Cell membrane; Multi-pass membrane protein.
Tissue Location Predominantly expressed in the thymus, in peripheral blood leukocytes, including T-cells, mostly CD4+ cells, and basophils, and in platelets; at lower levels, in the spleen and in monocytes. Detected also in macrophages, IL-2-activated natural killer cells and skin-homing memory T-cells, mostly the ones expressing the cutaneous lymphocyte antigen (CLA). Expressed in brain microvascular and coronary artery endothelial cells
Research Areas
Citations (0)

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The protein encoded by this gene belongs to theG-protein-coupled receptor family . It is a receptor for the CCchemokine - MIP-1, RANTES, TARC and MCP-1. Chemokines are a groupof small polypeptide, structurally related molecules that regulatecell trafficking of various types of leukocytes. The chemokinesalso play fundamental roles in the development, homeostasis, andfunction of the immune system, and they have effects on cells ofthe central nervous system as well as on endothelial cells involvedin angiogenesis or angiostasis.


Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Han, S., et al. Hum. Immunol. 71(7):727-730(2010)Rajaraman, P., et al. Cancer Epidemiol. Biomarkers Prev. 19(5):1356-1361(2010)Klapa, S., et al. Clin. Exp. Rheumatol. 28 (1 SUPPL 57), 72-80 (2010) :Maneechotesuwan, K., et al. J Med Assoc Thai 93 SUPPL 1, S62-S70 (2010) :

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$ 80.00
Cat# BP18134b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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