|Other Names||Bax inhibitor 1, BI-1, Testis-enhanced gene transcript protein, Transmembrane BAX inhibitor motif-containing protein 6, TMBIM6, BI1, TEGT|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Suppressor of apoptosis (PubMed:21075086). Modulates unfolded protein response signaling (PubMed:21075086). Modulates ER calcium homeostasis by acting as a calcium-leak channel (PubMed:22128171). Negatively regulates autophagy and autophagosome formation, especially during periods of nutrient deprivation, and reduces cell survival during starvation (By similarity).|
|Cellular Location||Endoplasmic reticulum membrane; Multi- pass membrane protein|
|Tissue Location||Highly abundant in testis.|
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TMBIM6 is a suppressor of apoptosis.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Lee, G.H., et al. Mol. Cell. Biol. 30(7):1800-1813(2010)Zhang, M., et al. Mol. Cell. Biochem. 333 (1-2), 1-7 (2010) :Kotsafti, A., et al. BMC Gastroenterol 10, 35 (2010) :Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
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