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TIPRL Antibody (C-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession O75663
Clone Names 90723261
Peptide ID 90723261
Additional Information
Gene ID 261726
Other Names TIP41-like protein, Putative MAPK-activating protein PM10, Type 2A-interacting protein, TIP, TIPRL
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name TIPRL
Function May be a allosteric regulator of serine/threonine- protein phosphatase 2A (PP2A). Isoform 1 inhibits catalytic activity of the PP2A(D) core complex in vitro. The PP2A(C):TIPRL complex does not show phosphatase activity. May play a role in the regulation of ATM/ATR signaling pathway controlling DNA replication and repair.
Cellular Location Cytoplasm.
Research Areas
Citations (0)

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Background

TIPRL is an inhibitory regulator of protein phosphatase-2A(PP2A) (see PPP2CA; MIM 176915), PP4 (see PPP4C; MIM 602035), andPP6 (see PPP6C; MIM 612725) (McConnell et al., 2007 [PubMed17384681]).

References

Ehret, G.B., et al. Eur. J. Hum. Genet. 17(12):1650-1657(2009)Cheung, C.L., et al. Hum. Mol. Genet. 18(4):679-687(2009)Rikova, K., et al. Cell 131(6):1190-1203(2007)McConnell, J.L., et al. Oncogene 26(41):6021-6030(2007)Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :

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$ 80.00
Cat# BP18140b
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