|Other Names||Filamin A-interacting protein 1-like, 130 kDa GPBP-interacting protein, 90 kDa GPBP-interacting protein, Protein down-regulated in ovarian cancer 1, DOC-1, FILIP1L, COL4A3BPIP, DOC1, GIP90|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||COL4A3BPIP, DOC1, GIP90|
|Function||Acts as a regulator of the antiangiogenic activity on endothelial cells. When overexpressed in endothelial cells, leads to inhibition of cell proliferation and migration and an increase in apoptosis. Inhibits melanoma growth When expressed in tumor- associated vasculature.|
|Cellular Location||Cytoplasm. Membrane. Nucleus|
|Tissue Location||Expressed in endothelial cells, colon and colon cancers. In the colon, expressed in the vasculature and muscularis mucosa. In colon cancer, strongly expressed in tumor stroma and the vasculature (at protein level). Expressed in ovarian epithelial cells. Down-regulated in ovarian cancer|
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Acts as a regulator of the antiangiogenic activity on endothelial cells. When overexpressed in endothelial cells, leads to inhibition of cell proliferation and migration and an increase in apoptosis. Inhibits melanoma growth When expressed in tumor-associated vasculature.
Notaridou, M., et al. Int. J. Cancer (2010) In press :Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Quaye, L., et al. Hum. Mol. Genet. 18(10):1869-1878(2009)Tandle, A.T., et al. Cytokine 30(6):347-358(2005)Mok, S.C., et al. Gynecol. Oncol. 52(2):247-252(1994)
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