|Other Names||Collectin-12, Collectin placenta protein 1, CL-P1, hCL-P1, Nurse cell scavenger receptor 2, Scavenger receptor class A member 4, Scavenger receptor with C-type lectin, COLEC12, CLP1, NSR2, SCARA4, SRCL|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||CLP1, NSR2, SCARA4, SRCL|
|Function||Scavenger receptor that displays several functions associated with host defense. Promotes binding and phagocytosis of Gram-positive, Gram-negative bacteria and yeast. Mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. Binds to several carbohydrates including Gal-type ligands, D-galactose, L- and D-fucose, GalNAc, T and Tn antigens in a calcium-dependent manner and internalizes specifically GalNAc in nurse-like cells. Binds also to sialyl Lewis X or a trisaccharide and asialo-orosomucoid (ASOR). May also play a role in the clearance of amyloid beta in Alzheimer disease.|
|Cellular Location||Membrane; Single-pass type II membrane protein. Note=Forms clusters on the cell surface|
|Tissue Location||Expressed in perivascular macrophages. Expressed in plaques-surrounding reactive astrocytes and in perivascular astrocytes associated with cerebral amyloid angiopathy (CAA) in the temporal cortex of Alzheimer patient (at protein level). Strongly expressed in placenta. Moderately expressed in heart, skeletal muscle, small intestine and lung Weakly expressed in brain, colon, thymus and kidney. Expressed in nurse-like cells. Expressed in reactive astrocytes and vascular/perivascular cells in the brain of Alzheimer patient|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the C-lectin family,proteins that possess collagen-like sequences and carbohydraterecognition domains. This protein is a scavenger receptor, a cellsurface glycoprotein that can bind to carbohydrate antigens onmicroorganisms facilitating their recognition and removal. Inaddition, these receptors can recognize oxidized phospholipids sothey may also participate in removing oxidatively damaged orapoptotic cells.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Davila, S., et al. Genes Immun. 11(3):232-238(2010)Liu, Y., et al. Mol. Psychiatry (2010) In press :Samsen, A., et al. Eur. J. Cell Biol. 89(1):87-94(2010)Jang, S., et al. J. Biol. Chem. 284(6):3956-3965(2009)
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