|Other Names||Bis(5'-adenosyl)-triphosphatase ENPP4, AP3A hydrolase, AP3Aase, Ectonucleotide pyrophosphatase/phosphodiesterase family member 4, E-NPP 4, NPP-4, ENPP4, KIAA0879, NPP4|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Hydrolyzes extracellular Ap3A into AMP and ADP, and Ap4A into AMP and ATP. Ap3A and Ap4A are diadenosine polyphosphates thought to induce proliferation of vascular smooth muscle cells. Acts as a procoagulant, mediating platelet aggregation at the site of nascent thrombus via release of ADP from Ap3A and activation of ADP receptors.|
|Cellular Location||Cell membrane; Single-pass type I membrane protein|
|Tissue Location||Expressed on the surface of vascular endothelia.|
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Provided below are standard protocols that you may find useful for product applications.
ENPP4 belongs to the nucleotide pyrophosphatase/phosphodiesterase family.
Olsen, J.V., et al. Cell 127(3):635-648(2006)Gijsbers, R., et al. J. Biol. Chem. 276(2):1361-1368(2001)
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