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SS18L1 Antibody (Center) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession O75177
Clone Names 90713250
Peptide ID 90713250
Additional Information
Gene ID 26039
Other Names Calcium-responsive transactivator, SS18-like protein 1, SYT homolog 1, SS18L1, CREST, KIAA0693
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name SS18L1
Synonyms CREST, KIAA0693
Function Transcriptional activator which is required for calcium- dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity).
Cellular Location Nucleus. Chromosome, centromere, kinetochore. Note=Localizes to nuclear bodies. Colocalizes with SGOL1 at kinetochore (By similarity)
Tissue Location Ubiquitous; with lowest levels in spleen.
Research Areas
Citations (0)

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Synovial sarcomas occur most frequently in the extremitiesaround large joints. More than 90% of cases have a recurrent andspecific chromosomal translocation, t(X;18)(p11.2;q11.2), in whichthe 5-prime end of the SS18 gene (MIM 600192) is fused in-frame tothe 3-prime end of the SSX1 (MIM 312820), SSX2 (MIM 300192), orSSX4 (MIM 300326) gene. The SS18L1 gene is homologous toSS18.


Yoshida, T., et al. Int. J. Mol. Med. 25(4):649-656(2010)Oguri, M., et al. Am. J. Hypertens. 23(1):70-77(2010)Yoshida, T., et al. Int. J. Mol. Med. 24(4):539-547(2009)de Bruijn, D.R., et al. Cytogenet. Genome Res. 112 (3-4), 222-226 (2006) :Pradhan, A., et al. J. Biol. Chem. 280(26):24738-24743(2005)

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$ 80.00
Cat# BP18184c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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