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PTHB1 Antibody (C-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q3SYG4
Clone Names 91109301
Additional Information
Gene ID 27241
Other Names Protein PTHB1, Bardet-Biedl syndrome 9 protein, Parathyroid hormone-responsive B1 gene protein, BBS9, PTHB1
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name BBS9
Synonyms PTHB1
Function The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. Required for proper BBSome complex assembly and its ciliary localization.
Cellular Location Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell projection, cilium membrane. Cytoplasm Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite
Tissue Location Widely expressed. Expressed in adult heart, skeletal muscle, lung, liver, kidney, placenta and brain, and in fetal kidney, lung, liver and brain.
Research Areas
Citations (0)
citation

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Background

This gene is downregulated by parathyroid hormone inosteoblastic cells, and therefore, is thought to be involved inparathyroid hormone action in bones. The exact function of thisgene has not yet been determined. Alternatively spliced transcriptvariants encoding different isoforms have been identified.

References

Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Wang, M., et al. Stat Biopharm Res 1(4):424-430(2009)Kang, H., et al. Hum. Reprod. 23(6):1457-1465(2008)Nachury, M.V., et al. Cell 129(6):1201-1213(2007)Nishimura, D.Y., et al. Am. J. Hum. Genet. 77(6):1021-1033(2005)

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$ 277.78
Cat# BP18186b
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