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PPIL2 Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q13356
Clone Names 100405104
Peptide ID 100405104
Additional Information
Gene ID 23759
Other Names Peptidyl-prolyl cis-trans isomerase-like 2, PPIase, PPIL2 (HGNC:9261)
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name PPIL2 (HGNC:9261)
Function May catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides thereby assisting the folding of proteins (By similarity). May also function as a chaperone, playing a role in transport to the cell membrane of BSG for instance (PubMed:15946952). May also have a protein ubiquitin ligase activity acting as an E3 ubiquitin protein ligase or as an ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on substrates. By mediating 'Lys-48'-linked polyubiquitination of proteins could target them for proteasomal degradation (PubMed:11435423).
Cellular Location Nucleus. Note=May also localize to the cytoplasm and the cell membrane.
Tissue Location Highest expression in thymus, pancreas and testis. Also detected in heart, placenta, lung, liver, skeletal muscle, kidney, spleen, prostate, ovary, small intestine and colon. Poorly detected in brain and leukocytes. Strong protein expression in lymph node (cortical, paracortical and medullar regions), thyroid (follicular epithelial cells), testis (developing spermatozoa), stomach (cells lining the gastric pit), pancreas, kidney (proximal and distal-tubule cells and collecting duct cells but not in glomeruli), endometrium and colon (goblet cells). Moderate protein expression in spleen, prostate (epithelium and squamous cell carcinomas), placenta and adrenal gland. Weak protein expression in liver, heart, breast, ovary, and lung. No protein expression in brain and bladder. High protein expression in most lymphomas and melanomas
Research Areas
Citations (0)

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This gene is a member of the cyclophilin family ofpeptidylprolyl isomerases. The cyclophilins are a highly conservedubiquitous family, members of which play an important role inprotein folding, immunosuppression by cyclosporin A, and infectionof HIV-1 virions. This protein interacts with the proteinaseinhibitor eglin c and is localized in the nucleus. Multipletranscript variants encoding different isoforms have been found forthis gene.


Carson, R., et al. Neuromolecular Med. 11(4):337-344(2009)Pushkarsky, T., et al. J. Biol. Chem. 280(30):27866-27871(2005)Hatakeyama, S., et al. J. Biol. Chem. 276(35):33111-33120(2001)Wang, B.B., et al. Biochem. J. 314 (PT 1), 313-319 (1996) :

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$ 80.00
Cat# BP18215b
Availability: In Stock
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