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BPHL Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q86WA6 |
|---|---|
| Clone Names | 100324276 |
| Gene ID | 670 |
|---|---|
| Other Names | Valacyclovir hydrolase, VACVase, Valacyclovirase, 31--, Biphenyl hydrolase-like protein, Biphenyl hydrolase-related protein, Bph-rp, Breast epithelial mucin-associated antigen, MCNAA, BPHL, MCNAA |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | BPHL |
|---|---|
| Synonyms | MCNAA |
| Function | Serine hydrolase that catalyzes the hydrolytic activation of amino acid ester prodrugs of nucleoside analogs such as valacyclovir and valganciclovir. Activates valacyclovir to acyclovir. May play a role in detoxification processes. It is a specific alpha-amino acid ester hydrolase that prefers small, hydrophobic, and aromatic side chains and does not have a stringent requirement for the leaving group other than preferring a primary alcohol. |
| Tissue Location | Expressed at high levels in liver and kidney and lower levels in heart, intestine and skeletal muscle |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the serine protease familyof hydrolytic enzymes which contain a serine in their active site.The encoded protein may play a role in activation of the antiviralprodrug valacyclovir. Alternatively spliced transcript variantshave been described.
References
Davila, S., et al. Genes Immun. 11(3):232-238(2010)Lai, L., et al. J. Biol. Chem. 283(14):9318-9327(2008)Grigo, K., et al. Biol. Chem. 389(2):179-187(2008)Melk, A., et al. Kidney Int. 68(6):2667-2679(2005)Kim, I., et al. Mol. Pharm. 1(6):434-446(2004)
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