|Other Names||Valacyclovir hydrolase, VACVase, Valacyclovirase, 31--, Biphenyl hydrolase-like protein, Biphenyl hydrolase-related protein, Bph-rp, Breast epithelial mucin-associated antigen, MCNAA, BPHL, MCNAA|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Serine hydrolase that catalyzes the hydrolytic activation of amino acid ester prodrugs of nucleoside analogs such as valacyclovir and valganciclovir. Activates valacyclovir to acyclovir. May play a role in detoxification processes. It is a specific alpha-amino acid ester hydrolase that prefers small, hydrophobic, and aromatic side chains and does not have a stringent requirement for the leaving group other than preferring a primary alcohol.|
|Tissue Location||Expressed at high levels in liver and kidney and lower levels in heart, intestine and skeletal muscle|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the serine protease familyof hydrolytic enzymes which contain a serine in their active site.The encoded protein may play a role in activation of the antiviralprodrug valacyclovir. Alternatively spliced transcript variantshave been described.
Davila, S., et al. Genes Immun. 11(3):232-238(2010)Lai, L., et al. J. Biol. Chem. 283(14):9318-9327(2008)Grigo, K., et al. Biol. Chem. 389(2):179-187(2008)Melk, A., et al. Kidney Int. 68(6):2667-2679(2005)Kim, I., et al. Mol. Pharm. 1(6):434-446(2004)
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