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BPHL Antibody (Center) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q86WA6
Clone Names 100324276
Peptide ID 100324276
Additional Information
Gene ID 670
Other Names Valacyclovir hydrolase, VACVase, Valacyclovirase, 31--, Biphenyl hydrolase-like protein, Biphenyl hydrolase-related protein, Bph-rp, Breast epithelial mucin-associated antigen, MCNAA, BPHL, MCNAA
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name BPHL
Synonyms MCNAA
Function Serine hydrolase that catalyzes the hydrolytic activation of amino acid ester prodrugs of nucleoside analogs such as valacyclovir and valganciclovir. Activates valacyclovir to acyclovir. May play a role in detoxification processes. It is a specific alpha-amino acid ester hydrolase that prefers small, hydrophobic, and aromatic side chains and does not have a stringent requirement for the leaving group other than preferring a primary alcohol.
Tissue Location Expressed at high levels in liver and kidney and lower levels in heart, intestine and skeletal muscle
Research Areas
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Background

This gene encodes a member of the serine protease familyof hydrolytic enzymes which contain a serine in their active site.The encoded protein may play a role in activation of the antiviralprodrug valacyclovir. Alternatively spliced transcript variantshave been described.

References

Davila, S., et al. Genes Immun. 11(3):232-238(2010)Lai, L., et al. J. Biol. Chem. 283(14):9318-9327(2008)Grigo, K., et al. Biol. Chem. 389(2):179-187(2008)Melk, A., et al. Kidney Int. 68(6):2667-2679(2005)Kim, I., et al. Mol. Pharm. 1(6):434-446(2004)

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$ 80.00
Cat# BP18229c
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