|Other Names||Pleckstrin homology domain-containing family A member 1, PH domain-containing family A member 1, Tandem PH domain-containing protein 1, TAPP-1, PLEKHA1, TAPP1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Binds specifically to phosphatidylinositol 3,4- diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane.|
|Cellular Location||Cytoplasm. Cell membrane; Peripheral membrane protein. Nucleus. Note=Locates to the plasma membrane after treatments that stimulate the production of PtdIns3,4P2|
|Tissue Location||Highly expressed in skeletal muscle, thymus, pancreas, placenta and lung. Detected at low levels in brain, heart, peripheral blood leukocytes, testis, ovary, spinal cord, thyroid, kidney, liver, small intestine and colon|
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This gene encodes a pleckstrin homology domain-containingadapter protein. The encoded protein is localized to the plasmamembrane where it specifically binds phosphatidylinositol3,4-bisphosphate. This protein may be involved in the formation ofsignaling complexes in the plasma membrane. Polymorphisms in thisgene are associated with age-related macular degeneration.Alternate splicing results in multiple transcript variants. Apseudogene of this gene is found on chromosome 5.
Deangelis, M.M., et al. Ophthalmology 115(7):1209-1215(2008)Manna, D., et al. J. Biol. Chem. 282(44):32093-32105(2007)Kanda, A., et al. Proc. Natl. Acad. Sci. U.S.A. 104(41):16227-16232(2007)Leveziel, N., et al. Mol. Vis. 13, 2153-2159 (2007) :Hogan, A., et al. J. Biol. Chem. 279(51):53717-53724(2004)
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