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TCF15 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q12870 |
|---|---|
| Clone Names | 110808056 |
| Gene ID | 6939 |
|---|---|
| Other Names | Transcription factor 15, TCF-15, Class A basic helix-loop-helix protein 40, bHLHa40, Paraxis, Protein bHLH-EC2, TCF15, BHLHA40, BHLHEC2 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | TCF15 (HGNC:11627) |
|---|---|
| Function | Early transcription factor that plays a key role in somitogenesis, paraxial mesoderm development and regulation of stem cell pluripotency. Essential for the mesenchymal to epithelial transition associated with somite formation. Required for somite morphogenesis, thereby regulating patterning of the axial skeleton and skeletal muscles. Required for proper localization of somite epithelium markers during the mesenchymal to epithelial transition. Also plays a key role in regulation of stem cell pluripotency. Promotes pluripotency exit of embryonic stem cells (ESCs) by priming ESCs for differentiation. Acts as a key regulator of self-renewal of hematopoietic stem cells (HSCs) by mediating HSCs quiescence and long- term self-renewal. Together with MEOX2, regulates transcription in heart endothelial cells to regulate fatty acid transport across heart endothelial cells. Acts by forming a heterodimer with another helix- loop-helix (bHLH) protein, such as TCF3/E12, that binds DNA on E-box motifs (5'-CANNTG-3') and activates transcription of target genes. |
| Cellular Location | Nucleus {ECO:0000250|UniProtKB:Q60756, ECO:0000255|PROSITE-ProRule:PRU00981} |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is found in the nucleusand may be involved in the early transcriptional regulation ofpatterning of the mesoderm. The encoded basic helix-loop-helixprotein requires dimerization with another basic helix-loop-helixprotein for efficient DNA binding.
References
Guo, P., et al. J. Biol. Chem. 284(27):18184-18193(2009)Deloukas, P., et al. Nature 414(6866):865-871(2001)Hidai, H., et al. Genomics 30(3):598-601(1995)Quertermous, E.E., et al. Proc. Natl. Acad. Sci. U.S.A. 91(15):7066-7070(1994)
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