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CIDEC Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q96AQ7 |
|---|---|
| Clone Names | 110808102 |
| Gene ID | 63924 |
|---|---|
| Other Names | Cell death activator CIDE-3, Cell death-inducing DFFA-like effector protein C, Fat-specific protein FSP27 homolog, CIDEC, FSP27 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | CIDEC {ECO:0000303|PubMed:20049731, ECO:0000312|HGNC:HGNC:24229} |
|---|---|
| Function | Lipid transferase specifically expressed in white adipose tissue, which promotes unilocular lipid droplet formation by mediating lipid droplet fusion (PubMed:18334488, PubMed:19843876, PubMed:20049731, PubMed:23399566, PubMed:30361435). Lipid droplet fusion promotes their enlargement, restricting lipolysis and favoring lipid storage (PubMed:18334488, PubMed:19843876, PubMed:20049731, PubMed:23399566). Localizes on the lipid droplet surface, at focal contact sites between lipid droplets, and mediates atypical lipid droplet fusion by undergoing liquid-liquid phase separation (LLPS) and promoting directional net neutral lipid transfer from the smaller to larger lipid droplets (PubMed:18334488, PubMed:19843876, PubMed:20049731, PubMed:23399566). The transfer direction may be driven by the internal pressure difference between the contacting lipid droplet pair (PubMed:18334488, PubMed:19843876, PubMed:20049731, PubMed:23399566). Its role in neutral lipid transfer and lipid droplet enlargement is activated by the interaction with PLIN1 (PubMed:23399566). May also act as a CEBPB coactivator in the white adipose tissue to control the expression of a subset of CEBPB downstream target genes, including SOCS1, SOCS3, TGFB1, TGFBR1, ID2 and XDH (By similarity). When overexpressed in preadipocytes, induces apoptosis or increases cell susceptibility to apoptosis induced by serum deprivation or TGFB treatment (PubMed:12429024). |
| Cellular Location | Lipid droplet. Endoplasmic reticulum {ECO:0000250|UniProtKB:P56198}. Nucleus {ECO:0000250|UniProtKB:P56198} Note=Diffuses quickly on lipid droplet surface, but becomes trapped and clustered at lipid droplet contact sites, thereby enabling its rapid enrichment at lipid droplet contact sites {ECO:0000250|UniProtKB:P56198} |
| Tissue Location | Expressed mainly in adipose tissue, small intestine, heart, colon and stomach and, at lower levels, in brain, kidney and liver. |
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Provided below are standard protocols that you may find useful for product applications.
Background
DNA fragmentation factor (DFF) induces the fragmentationof DNA associated with apoptosis. A novel family of celldeath-inducing DFF45 (MIM 601882)-like effectors (CIDEs), includingCIDEC, can also promote apoptosis (Liang et al., 2003 [PubMed12429024]).
References
Ito, M., et al. J. Lipid Res. 51(7):1676-1684(2010)Nian, Z., et al. J. Biol. Chem. 285(13):9604-9615(2010)Hall, A.M., et al. Obesity (Silver Spring) 18(2):417-419(2010)Rubio-Cabezas, O., et al. EMBO Mol Med 1(5):280-287(2009)Magnusson, B., et al. Metab. Clin. Exp. 57(9):1307-1313(2008)
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