SGPP2 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q8IWX5 |
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Clone Names | 110808272 |
Gene ID | 130367 |
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Other Names | Sphingosine-1-phosphate phosphatase 2, SPPase2, Spp2, hSPP2, 313-, Sphingosine-1-phosphatase 2, SGPP2 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | SGPP2 (HGNC:19953) |
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Function | Has specific phosphohydrolase activity towards sphingoid base 1-phosphates. Has high phosphohydrolase activity against dihydrosphingosine-1-phosphate and sphingosine-1-phosphate (S1P) in vitro (PubMed:12411432). Sphingosine-1-phosphate phosphatase activity is needed for efficient recycling of sphingosine into the sphingolipid synthesis pathway (By similarity). May play a role in attenuating intracellular sphingosine 1-phosphate (S1P) signaling. May play a role in pro-inflammatory signaling (PubMed:17113265). Plays a role in the regulation of pancreatic islet beta-cell endoplasmic reticulum stress and proliferation (By similarity). |
Cellular Location | Endoplasmic reticulum membrane; Multi-pass membrane protein |
Tissue Location | Expressed strongly in kidney and heart, followed by brain, colon, small intestine and lung. Not detected in skeletal muscle, thymus, spleen, liver, placenta, and peripheral blood leukocytes. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Sphingosine-1-phosphate (S1P) is a bioactive sphingolipidmetabolite that regulates diverse biologic processes. SGPP2catalyzes the degradation of S1P (Ogawa et al., 2003 [PubMed12411432]).
References
Mechtcheriakova, D., et al. Cell. Signal. 19(4):748-760(2007)Ogawa, C., et al. J. Biol. Chem. 278(2):1268-1272(2003)
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