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SGPP2 Antibody (N-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q8IWX5
Clone Names 110808272
Additional Information
Gene ID 130367
Other Names Sphingosine-1-phosphate phosphatase 2, SPPase2, Spp2, hSPP2, 313-, Sphingosine-1-phosphatase 2, SGPP2
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name SGPP2 (HGNC:19953)
Function Has specific phosphohydrolase activity towards sphingoid base 1-phosphates. Has high phosphohydrolase activity against dihydrosphingosine-1-phosphate and sphingosine-1-phosphate (S1P) in vitro (PubMed:12411432). Sphingosine-1-phosphate phosphatase activity is needed for efficient recycling of sphingosine into the sphingolipid synthesis pathway (By similarity). May play a role in attenuating intracellular sphingosine 1-phosphate (S1P) signaling. May play a role in pro-inflammatory signaling (PubMed:17113265). Plays a role in the regulation of pancreatic islet beta-cell endoplasmic reticulum stress and proliferation (By similarity).
Cellular Location Endoplasmic reticulum membrane; Multi-pass membrane protein
Tissue Location Expressed strongly in kidney and heart, followed by brain, colon, small intestine and lung. Not detected in skeletal muscle, thymus, spleen, liver, placenta, and peripheral blood leukocytes.
Research Areas
Citations (0)
citation

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Background

Sphingosine-1-phosphate (S1P) is a bioactive sphingolipidmetabolite that regulates diverse biologic processes. SGPP2catalyzes the degradation of S1P (Ogawa et al., 2003 [PubMed12411432]).

References

Mechtcheriakova, D., et al. Cell. Signal. 19(4):748-760(2007)Ogawa, C., et al. J. Biol. Chem. 278(2):1268-1272(2003)

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$ 277.78
Cat# BP18254a
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