|Other Names||DNA damage-regulated autophagy modulator protein 1, Damage-regulated autophagy modulator, DRAM1, DRAM|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP1825b was selected from the C-term-2 region of human DRAM. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Lysosomal modulator of autophagy that plays a central role in p53/TP53-mediated apoptosis. Not involved in p73/TP73- mediated autophagy.|
|Cellular Location||Lysosome membrane; Multi-pass membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
DRAM is regulated as part of the p53 tumor suppressor pathway. It is a lysosomal membrane protein that is required for the induction of autophagy by the pathway. Decreased transcriptional expression of the gene encoding DRAM is associated with various tumors.
Kerley-Hamilton,J.S., Biochim. Biophys. Acta 1769 (4), 209-219 (2007)Crighton,D., Autophagy 3 (1), 72-74 (2007)Crighton,D., Cell 126 (1), 121-134 (2006)Green,D.R., Cell 126 (1), 30-32 (2006)
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