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DPH2 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9BQC3 |
|---|---|
| Clone Names | 110811061 |
| Gene ID | 1802 |
|---|---|
| Other Names | Diphthamide biosynthesis protein 2, DPH2 homolog, HsDph2, Diphthamide biosynthesis protein 2 homolog-like 2, DPH2-like 2, DPH2, DPH2L2 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | DPH2 |
|---|---|
| Synonyms | DPH2L2 |
| Function | Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2 (PubMed:32576952). DPH1 and DPH2 transfer a 3-amino-3- carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase (By similarity). Facilitates the reduction of the catalytic iron-sulfur cluster found in the DPH1 subunit (By similarity). |
| Tissue Location | Strongly expressed in skeletal muscle. Moderately expressed in heart, small intestine, liver, pancreas, testis and colon Weakly expressed in brain, placenta, kidney, spleen, thymus, prostate, ovary and lymphocytes. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene is one of two human genes similar to the yeastgene dph2. The yeast gene was identified by its ability tocomplement a diphthamide mutant strain, and thus probably functionsin diphthamide biosynthesis. Diphthamide is a post-translationallymodified histidine residue present in elongation factor 2 (EF2)that is the target of diphtheria toxin ADP-ribosylation. Twotranscript variants encoding different isoforms have been found forthis gene.
References
Rose, J. Phd, et al. Mol. Med. (2010) In press :Liu, S., et al. Mol. Cell. Biol. 24(21):9487-9497(2004)Schultz, D.C., et al. Genomics 52(2):186-191(1998)Foley, B.T., et al. J. Biol. Chem. 270(39):23218-23225(1995)Mattheakis, L.C., et al. Gene 132(1):149-154(1993)
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