|Other Names||Diphthamide biosynthesis protein 2, DPH2 homolog, HsDph2, Diphthamide biosynthesis protein 2 homolog-like 2, DPH2-like 2, DPH2, DPH2L2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2).|
|Tissue Location||Strongly expressed in skeletal muscle. Moderately expressed in heart, small intestine, liver, pancreas, testis and colon. Weakly expressed in brain, placenta, kidney, spleen, thymus, prostate, ovary and lymphocytes|
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Provided below are standard protocols that you may find useful for product applications.
This gene is one of two human genes similar to the yeastgene dph2. The yeast gene was identified by its ability tocomplement a diphthamide mutant strain, and thus probably functionsin diphthamide biosynthesis. Diphthamide is a post-translationallymodified histidine residue present in elongation factor 2 (EF2)that is the target of diphtheria toxin ADP-ribosylation. Twotranscript variants encoding different isoforms have been found forthis gene.
Rose, J. Phd, et al. Mol. Med. (2010) In press :Liu, S., et al. Mol. Cell. Biol. 24(21):9487-9497(2004)Schultz, D.C., et al. Genomics 52(2):186-191(1998)Foley, B.T., et al. J. Biol. Chem. 270(39):23218-23225(1995)Mattheakis, L.C., et al. Gene 132(1):149-154(1993)
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