|Other Names||tRNA-dihydrouridine(20) synthase [NAD(P)+]-like, 131-, Dihydrouridine synthase 2, Up-regulated in lung cancer protein 8, URLC8, tRNA-dihydrouridine synthase 2-like, hDUS2, DUS2, DUS2L|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Dihydrouridine synthase. Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Negatively regulates the activation of EIF2AK2/PKR.|
|Cellular Location||Cytoplasm. Endoplasmic reticulum. Note=Mainly at the endoplasmic reticulum|
|Tissue Location||Weak expression in heart, placenta and skeletal muscle. Up-regulated in most lung cancer cells (at protein level).|
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Provided below are standard protocols that you may find useful for product applications.
Dihydrouridine synthase catalyzes reduction of the5,6-double bond of a uridine residue on the displacement loop oftRNA. The resultant modified base, 5,6-dihydrouridine, appears toincrease the conformational flexibility and dynamic motion of tRNA(Kato et al., 2005 [PubMed 15994936]).
Mittelstadt, M., et al. Nucleic Acids Res. 36(3):998-1008(2008)Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)Lamesch, P., et al. Genomics 89(3):307-315(2007)Kato, T., et al. Cancer Res. 65(13):5638-5646(2005)
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