|Other Names||tRNA-dihydrouridine(20) synthase [NAD(P)+]-like, 131-, Dihydrouridine synthase 2, Up-regulated in lung cancer protein 8, URLC8, tRNA-dihydrouridine synthase 2-like, hDUS2, DUS2, DUS2L|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Dihydrouridine synthase. Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Negatively regulates the activation of EIF2AK2/PKR.|
|Cellular Location||Cytoplasm. Endoplasmic reticulum. Note=Mainly at the endoplasmic reticulum|
|Tissue Location||Weak expression in heart, placenta and skeletal muscle. Up-regulated in most lung cancer cells (at protein level).|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
firstname.lastname@example.org, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Dihydrouridine synthase catalyzes reduction of the5,6-double bond of a uridine residue on the displacement loop oftRNA. The resultant modified base, 5,6-dihydrouridine, appears toincrease the conformational flexibility and dynamic motion of tRNA(Kato et al., 2005 [PubMed 15994936]).
Mittelstadt, M., et al. Nucleic Acids Res. 36(3):998-1008(2008)Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)Lamesch, P., et al. Genomics 89(3):307-315(2007)Kato, T., et al. Cancer Res. 65(13):5638-5646(2005)
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at email@example.com.