|Other Names||Activating molecule in BECN1-regulated autophagy protein 1, AMBRA1, KIAA1736|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP1826b was selected from the C-term region of human AMBRA1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Regulates autophagy and development of the nervous system. Involved in autophagy in controlling protein turnover during neuronal development, and in regulating normal cell survival and proliferation (By similarity).|
|Cellular Location||Cytoplasmic vesicle, autophagosome. Note=Localizes also to discrete punctae along the ciliary axoneme.|
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Provided below are standard protocols that you may find useful for product applications.
AMBRA1 regulates autophagy and development of the nervous system. This protein is involved in autophagy in controlling protein turnover during neuronal development, and in regulating normal cell survival and proliferation.
Maria Fimia G.,Nature 447:1121-1125(2007).Nagase T.,DNA Res. 7:347-355(2000).Ota T.,Nat. Genet. 36:40-45(2004).
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