|Other Names||HAUS augmin-like complex subunit 8, HEC1/NDC80-interacting centrosome-associated protein 1, Sarcoma antigen NY-SAR-48, HAUS8, HICE1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex.|
|Cellular Location||Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole Note=During interphase, primarily cytoplasmic and associates with centrosomes and with the mitotic spindles, preferentially at the spindle pole vicinity. During anaphase and telophase, additionally associates with the spindle midzone and midbody, respectively|
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Provided below are standard protocols that you may find useful for product applications.
HAUS8 is 1 of 8 subunits of the 390-kD human augmincomplex, or HAUS complex. The augmin complex was first identifiedin Drosophila, and its name comes from the Latin verb 'augmentare,'meaning 'to increase.' The augmin complex is a microtubule-bindingcomplex involved in microtubule generation within the mitoticspindle and is vital to mitotic spindle assembly (Goshima et al.,2008 [PubMed 18443220]; Uehara et al., 2009 [PubMed19369198]).
Wu, G., et al. Mol. Biol. Cell 20(22):4686-4695(2009)Lawo, S., et al. Curr. Biol. 19(10):816-826(2009)Uehara, R., et al. Proc. Natl. Acad. Sci. U.S.A. 106(17):6998-7003(2009)Wu, G., et al. Mol. Cell. Biol. 28(11):3652-3662(2008)Goshima, G., et al. J. Cell Biol. 181(3):421-429(2008)
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