|Other Names||Mediator of RNA polymerase II transcription subunit 18, Mediator complex subunit 18, p28b, MED18|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|
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Provided below are standard protocols that you may find useful for product applications.
MED18 is a component of the Mediator complex, which is acoactivator for DNA-binding factors that activate transcription viaRNA polymerase II (Sato et al., 2003 [PubMed 12584197]).[suppliedby OMIM].
Sato, S., et al. Mol. Cell 14(5):685-691(2004)Tomomori-Sato, C., et al. J. Biol. Chem. 279(7):5846-5851(2004)Sato, S., et al. J. Biol. Chem. 278(50):49671-49674(2003)Sato, S., et al. J. Biol. Chem. 278(17):15123-15127(2003)
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