|Other Names||Lysosome-associated membrane glycoprotein 3, LAMP-3, Lysosomal-associated membrane protein 3, DC-lysosome-associated membrane glycoprotein, DC LAMP, Protein TSC403, CD208, LAMP3, DCLAMP, TSC403|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP1827a was selected from the N-term region of human LAMP3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May play a role in dendritic cell function and in adaptive immunity.|
|Cellular Location||Lysosome membrane; Single- pass type I membrane protein. Cytoplasmic vesicle membrane; Single-pass type I membrane protein. Note=During dendritic cell maturation, detected on cytoplasmic vesicles (the MHC II compartment) that contain MHC II proteins, LAMP1, LAMP2 and LAMP3 (PubMed:9768752) Detected on lysosomes in mature dendritic cells (PubMed:9768752)|
|Tissue Location||Detected in tonsil interdigitating dendritic cells, in spleen, lymph node, Peyer's patches in the small instestine, in thymus medulla and in B-cells (at protein level) Expressed in lymphoid organs and dendritic cells. Expressed in lung. Up-regulated in carcinomas of the esophagus, colon, rectum, ureter, stomach, breast, fallopian tube, thyroid and parotid tissues.|
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Provided below are standard protocols that you may find useful for product applications.
LAMP3 is a member of a family of membrane glycoproteins. It may change lysosome function after the transfer of peptide-MHC class II molecules to the surface of dendritic cells.
Elliott,B., Clin. Cancer Res. 13 (13), 3825-3830 (2007)Zhu,L.C., Hum. Pathol. 38 (2), 260-268 (2007)Arruda,L.B., J. Immunol. 177 (4), 2265-2275 (2006)
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