|Other Names||Zinc finger protein 57 homolog, Zfp-57, Zinc finger protein 698, ZFP57, C6orf40, ZNF698|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Binds to a 5'-TGCCGC-3' consensus sequence and recognizes the methylated CpG within this element (By similarity). Transcription regulator required to maintain maternal and paternal gene imprinting, a process by which gene expression is restricted in a parent of origin-specific manner by epigenetic modification of genomic DNA and chromatin, including DNA methylation. Acts by controlling DNA methylation during the earliest multicellular stages of development at multiple imprinting control regions. Required for the establishment of maternal methylation imprints at SNRPN locus. Acts as a transcriptional repressor in Schwann cells.|
|Cellular Location||Nucleus. Note=Binds various differentially methylated regions (DMR), including the SNRPN DMR|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a zinc finger proteincontaining a KRAB domain. Studies in mouse suggest that thisprotein may function as a transcriptional repressor. Mutations inthis gene have been associated with transient neonatal diabetesmellitus type 1 (TNDM1).
Spengler, S., et al. Eur J Med Genet 52(6):415-416(2009)Barcellos, L.F., et al. PLoS Genet. 5 (10), E1000696 (2009) :Tse, K.P., et al. Am. J. Hum. Genet. 85(2):194-203(2009)Li, X., et al. Dev. Cell 15(4):547-557(2008)Mackay, D.J., et al. Nat. Genet. 40(8):949-951(2008)
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