MPG Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P29372 |
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Clone Names | 80902032 |
Gene ID | 4350 |
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Other Names | DNA-3-methyladenine glycosylase, 3-alkyladenine DNA glycosylase, 3-methyladenine DNA glycosidase, ADPG, N-methylpurine-DNA glycosylase, MPG, AAG, ANPG, MID1 |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP1829b was selected from the C-term region of human MPG. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | MPG |
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Synonyms | AAG, ANPG, MID1 |
Function | Hydrolysis of the deoxyribose N-glycosidic bond to excise 3- methyladenine, and 7-methylguanine from the damaged DNA polymer formed by alkylation lesions. |
Cellular Location | Cytoplasm. Mitochondrion matrix, mitochondrion nucleoid. Nucleus |
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Provided below are standard protocols that you may find useful for product applications.
Background
Hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine, and 7-methylguanine from the damaged DNA polymer formed by alkylation lesions.
References
Lee,C.Y., Delaney,J.C. Biochemistry 48 (9), 1850-1861 (2009)Chen,C.Y., Guo,H.H. DNA Repair (Amst.) 7 (10), 1731-1745 (2008)Chakravarti,D., Ibeanu,G.C. J. Biol. Chem. 266 (24), 15710-15715 (1991)
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