|Other Names||DNA-3-methyladenine glycosylase, 3-alkyladenine DNA glycosylase, 3-methyladenine DNA glycosidase, ADPG, N-methylpurine-DNA glycosylase, MPG, AAG, ANPG, MID1|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP1829b was selected from the C-term region of human MPG. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||AAG, ANPG, MID1|
|Function||Hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine, and 7-methylguanine from the damaged DNA polymer formed by alkylation lesions.|
|Cellular Location||Cytoplasm. Mitochondrion matrix, mitochondrion nucleoid. Nucleus|
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Provided below are standard protocols that you may find useful for product applications.
Hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine, and 7-methylguanine from the damaged DNA polymer formed by alkylation lesions.
Lee,C.Y., Delaney,J.C. Biochemistry 48 (9), 1850-1861 (2009)Chen,C.Y., Guo,H.H. DNA Repair (Amst.) 7 (10), 1731-1745 (2008)Chakravarti,D., Ibeanu,G.C. J. Biol. Chem. 266 (24), 15710-15715 (1991)
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