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HSD3B2 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P26439 |
|---|---|
| Clone Names | 81110086 |
| Gene ID | 3284 |
|---|---|
| Other Names | 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2, 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II, 3-beta-HSD II, 3-beta-HSD adrenal and gonadal type, 3-beta-hydroxy-Delta(5)-steroid dehydrogenase, 3-beta-hydroxy-5-ene steroid dehydrogenase, Progesterone reductase, Steroid Delta-isomerase, Delta-5-3-ketosteroid isomerase, HSD3B2, HSDB3B |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | HSD3B2 (HGNC:5218) |
|---|---|
| Synonyms | HSDB3B |
| Function | 3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. |
| Cellular Location | Endoplasmic reticulum membrane; Single-pass membrane protein. Mitochondrion membrane; Single-pass membrane protein |
| Tissue Location | Expressed in adrenal gland, testis and ovary. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a bifunctional enzymethat catalyzes the oxidative conversion ofdelta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversionof ketosteroids. It plays a crucial role in the biosynthesis of allclasses of hormonal steroids. This gene is predominantly expressedin the adrenals and the gonads. Mutations in this gene areassociated with 3-beta-hydroxysteroid dehydrogenase, type II,deficiency. Alternatively spliced transcript variants have beenfound for this gene.
References
Canzian, F., et al. Hum. Mol. Genet. 19(19):3873-3884(2010)Shimodaira, M., et al. Eur. J. Endocrinol. 163(4):671-680(2010)Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Liu, C.Y., et al. Carcinogenesis 31(7):1259-1263(2010)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
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