|Other Names||CUGBP Elav-like family member 5, CELF-5, Bruno-like protein 5, CUG-BP- and ETR-3-like factor 5, RNA-binding protein BRUNOL-5, CELF5, BRUNOL5|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||RNA-binding protein implicated in the regulation of pre- mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA.|
|Cellular Location||Nucleus. Cytoplasm|
|Tissue Location||Expressed in brain.|
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Members of the CELF/BRUNOL protein family contain twoN-terminal RNA recognition motif (RRM) domains, one C-terminal RRMdomain, and a divergent segment of 160-230 aa between the secondand third RRM domains. Members of this protein family regulatepre-mRNA alternative splicing and may also be involved in mRNAediting, and translation. Alternatively spliced transcript variantshave been identified in this gene.
Ladd, A.N., et al. Mol. Cell. Biol. 21(4):1285-1296(2001)Good, P.J., et al. J. Biol. Chem. 275(37):28583-28592(2000)
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