|Other Names||Cyclin-F, F-box only protein 1, CCNF, FBX1, FBXO1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication.|
|Cellular Location||Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole Note=Localization in the centrosome is rare in S phase cells and increases in G2 cells, Localizes on both the mother and daughter centrioles. Localization to centrosomes is not dependent on CP110 Also localizes to the nucleus|
|Tissue Location||Widely expressed.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the cyclin family. Cyclinsare important regulators of cell cycle transitions through theirability to bind and activate cyclin-dependent protein kinases. Thismember also belongs to the F-box protein family which ischaracterized by an approximately 40 amino acid motif, the F-box.The F-box proteins constitute one of the four subunits of theubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box),which function in phosphorylation-dependent ubiquitination. TheF-box proteins are divided into 3 classes: Fbws containing WD-40domains, Fbls containing leucine-rich repeats, and Fbxs containingeither different protein-protein interaction modules or norecognizable motifs. The protein encoded by this gene belongs tothe Fbxs class and it was one of the first proteins in which theF-box motif was identified.
D'Angiolella, V., et al. Nature 466(7302):138-142(2010)Fung, T.K., et al. J. Biol. Chem. 277(38):35140-35149(2002)Kong, M., et al. EMBO J. 19(6):1378-1388(2000)Bai, C., et al. Cell 86(2):263-274(1996)Bai, C., et al. EMBO J. 13(24):6087-6098(1994)
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