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CCNF Antibody (Center) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession P41002
Clone Names 90904023
Peptide ID 90904023
Additional Information
Gene ID 899
Other Names Cyclin-F, F-box only protein 1, CCNF, FBX1, FBXO1
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms FBX1, FBXO1
Function Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication.
Cellular Location Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole Note=Localization in the centrosome is rare in S phase cells and increases in G2 cells, Localizes on both the mother and daughter centrioles. Localization to centrosomes is not dependent on CP110 Also localizes to the nucleus
Tissue Location Widely expressed.
Research Areas
Citations (0)

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This gene encodes a member of the cyclin family. Cyclinsare important regulators of cell cycle transitions through theirability to bind and activate cyclin-dependent protein kinases. Thismember also belongs to the F-box protein family which ischaracterized by an approximately 40 amino acid motif, the F-box.The F-box proteins constitute one of the four subunits of theubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box),which function in phosphorylation-dependent ubiquitination. TheF-box proteins are divided into 3 classes: Fbws containing WD-40domains, Fbls containing leucine-rich repeats, and Fbxs containingeither different protein-protein interaction modules or norecognizable motifs. The protein encoded by this gene belongs tothe Fbxs class and it was one of the first proteins in which theF-box motif was identified.


D'Angiolella, V., et al. Nature 466(7302):138-142(2010)Fung, T.K., et al. J. Biol. Chem. 277(38):35140-35149(2002)Kong, M., et al. EMBO J. 19(6):1378-1388(2000)Bai, C., et al. Cell 86(2):263-274(1996)Bai, C., et al. EMBO J. 13(24):6087-6098(1994)

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$ 80.00
Cat# BP18322c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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