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ZSCAN4 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q8NAM6 |
|---|---|
| Clone Names | 110808376 |
| Gene ID | 201516 |
|---|---|
| Other Names | Zinc finger and SCAN domain-containing protein 4, Zinc finger protein 494, ZSCAN4, ZNF494 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | ZSCAN4 |
|---|---|
| Synonyms | ZNF494 |
| Function | Embryonic stem (ES) cell-specific transcription factor required to regulate ES cell pluripotency. Binds telomeres and plays a key role in genomic stability in ES cells by regulating telomere elongation. Acts as an activator of spontaneous telomere sister chromatid exchange (T-SCE) and telomere elongation in undifferentiated ES cells (By similarity). |
| Cellular Location | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00187}. Chromosome, telomere |
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Provided below are standard protocols that you may find useful for product applications.
Background
The ZSCAN4 gene encodes a protein involved in telomeremaintenance and with a key role in the critical feature of mouseembryonic stem (ES) cells, namely, defying cellular senescence andmaintaining normal karyotype for many cell divisions in culture(Zalzman et al., 2010 [PubMed 20336070]).
References
Zalzman, M., et al. Nature 464(7290):858-863(2010)Colland, F., et al. Genome Res. 14(7):1324-1332(2004)
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