|Other Names||Sodium-coupled neutral amino acid transporter 2, Amino acid transporter A2, Protein 40-9-1, Solute carrier family 38 member 2, System A amino acid transporter 2, System A transporter 1, System N amino acid transporter 2, SLC38A2, ATA2, KIAA1382, SAT2, SNAT2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||ATA2, KIAA1382, SAT2, SNAT2|
|Function||Functions as a sodium-dependent amino acid transporter. Mediates the saturable, pH-sensitive and electrogenic cotransport of neutral amino acids and sodium ions with a stoichiometry of 1:1. May function in the transport of amino acids at the blood- brain barrier and in the supply of maternal nutrients to the fetus through the placenta.|
|Cellular Location||Cell membrane; Multi-pass membrane protein Note=Insulin promotes recruitment to the plasma membrane from a pool localized in the trans-Golgi network or endosomes (By similarity). Enriched in the somatodendritic compartment of neurons, it is also detected at the axonal shaft but excluded from the nerve terminal.|
|Tissue Location||Ubiquitously expressed. Widely expressed in the central nervous system with higher concentrations in caudal regions. Expressed by glutamatergic and GABAergic neurons together with astrocytes and other non-neuronal cells in the cerebral cortex (at protein level).|
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SLC38A2 functions as a sodium-dependent amino acid transporter. Mediates the saturable, pH-sensitive and electrogenic cotransport of neutral amino acids and sodium ions with a stoichiometry of 1:1. May function in the transport of amino acids at the blood-brain barrier and in the supply of maternal nutrients to the fetus through the placenta.
Lewis, R.M., et al. Placenta 31(5):418-422(2010)Jones, H.N., et al. Am. J. Physiol., Cell Physiol. 297 (5), C1228-C1235 (2009) :Zhang, Z., et al. J. Biol. Chem. 284(37):25314-25323(2009)Iruloh, C.G., et al. Pediatr. Res. 65(1):51-56(2009)Gjymishka, A., et al. J. Biol. Chem. 283(41):27736-27747(2008)
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