|Other Names||Anoctamin-1, Discovered on gastrointestinal stromal tumors protein 1, Oral cancer overexpressed protein 2, Transmembrane protein 16A, Tumor-amplified and overexpressed sequence 2, ANO1, DOG1, ORAOV2, TAOS2, TMEM16A|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||DOG1, ORAOV2, TAOS2, TMEM16A|
|Function||Calcium-activated chloride channel (CaCC) which plays a role in transepithelial anion transport and smooth muscle contraction. Required for the normal functioning of the interstitial cells of Cajal (ICCs) which generate electrical pacemaker activity in gastrointestinal smooth muscles. Acts as a major contributor to basal and stimulated chloride conductance in airway epithelial cells and plays an important role in tracheal cartilage development.|
|Cellular Location||Cell membrane; Multi-pass membrane protein. Cytoplasm. Note=Cytoplasmic localization seen in neoplastic cells of head and neck squamous cell carcinoma (HNSCC) tumors|
|Tissue Location||Broadly expressed with higher levels in liver, skeletal muscle and gastrointestinal muscles|
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Provided below are standard protocols that you may find useful for product applications.
ANO1 acts as a calcium-activated chloride channel. Required for normal tracheal development (By similarity).
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Barro-Soria, R., et al. Pflugers Arch. 459(3):485-497(2010)Hosgood, H.D. III, et al. Occup Environ Med 66(12):848-853(2009)Ferrera, L., et al. J. Biol. Chem. 284(48):33360-33368(2009)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
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