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ABCC9 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | O60706 |
|---|---|
| Clone Names | 100311250 |
| Gene ID | 10060 |
|---|---|
| Other Names | ATP-binding cassette sub-family C member 9, Sulfonylurea receptor 2, ABCC9, SUR2 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | ABCC9 |
|---|---|
| Synonyms | SUR2 {ECO:0000303|PubMed:31575858} |
| Function | Subunit of ATP-sensitive potassium channels (KATP). Can form cardiac and smooth muscle-type KATP channels with KCNJ11. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation. |
| Cellular Location | Membrane {ECO:0000255|PROSITE-ProRule:PRU00441}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00441} |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a member of thesuperfamily of ATP-binding cassette (ABC) transporters. ABCproteins transport various molecules across extra- andintra-cellular membranes. ABC genes are divided into seven distinctsubfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). Thisprotein is a member of the MRP subfamily which is involved inmulti-drug resistance. This protein is thought to formATP-sensitive potassium channels in cardiac, skeletal, and vascularand non-vascular smooth muscle. Protein structure suggests a roleas the drug-binding channel-modulating subunit of theextrapancreatic ATP-sensitive potassium channels. No disease hasbeen associated with this gene thus far. Alternative splicing ofthis gene results in several products, two of which result fromdifferential usage of two terminal exons and one of which resultsfrom exon deletion.
References
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Zimmerman, R.S., et al. Genet. Med. 12(5):268-278(2010)Ellis, J.A., et al. Physiol. Genomics 40(3):184-188(2010)Kim, S.J., et al. Biochem. Biophys. Res. Commun. 391(1):974-978(2010)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
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