|Other Names||NADPH oxidase 3, 163-, Mitogenic oxidase 2, MOX-2, gp91phox homolog 3, GP91-3, NOX3, MOX2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||NADPH oxidase which constitutively produces superoxide upon formation of a complex with CYBA/p22phox. Plays a role in the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity.|
|Cellular Location||Membrane; Multi-pass membrane protein|
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This gene encodes a member of the NOX family of NADPHoxidases. These enzymes have the capacity to generate superoxideand other reactive oxygen species (ROS) and transport electronsacross the plasma membrane. The ROS generated by family membershave been implicated in numerous biological functions includinghost defense, posttranlational processing of proteins, cellularsignaling, regulation of gene expression, and cell differentiation.The protein encoded by this gene is expressed predominantly in theinner ear and is involved in the biogenesis of otoconia/otolith,which are crystalline structures of the inner ear involved in theperception of gravity.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Gao, D., et al. J. Biol. Chem. 285(39):29965-29973(2010)Li, L., et al. FEBS Lett. 584(5):995-1000(2010)Segat, L., et al. Vaccine 28(10):2201-2206(2010)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
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