|Other Names||Uridine-cytidine kinase 1, UCK 1, Cytidine monophosphokinase 1, Uridine monophosphokinase 1, UCK1, URK1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate. Does not phosphorylate deoxyribonucleosides or purine ribonucleosides. Can use ATP or GTP as a phosphate donor. Can also phosphorylate cytidine and uridine nucleoside analogs such as 6-azauridine, 5-fluorouridine, 4- thiouridine, 5-bromouridine, N(4)-acetylcytidine, N(4)- benzoylcytidine, 5-fluorocytidine, 2-thiocytidine, 5- methylcytidine, and N(4)-anisoylcytidine.|
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Provided below are standard protocols that you may find useful for product applications.
Uridine/cytidine kinase-1 (EC 220.127.116.11) is a pyrimidineribonucleoside kinase that catalyzes the phosphorylation of uridineand cytidine to form uridine monophosphate (UMP) and cytidinemonophosphate (CMP) (Van Rompay et al., 2001 [PubMed11306702]).
Virovic Jukic, L., et al. J. Biomed. Sci. 15(2):205-213(2008)Humphray, S.J., et al. Nature 429(6990):369-374(2004)Van Rompay, A.R., et al. Mol. Pharmacol. 59(5):1181-1186(2001)
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