|Other Names||Nuclear RNA export factor 5, TAP-like protein 1, TAPL-1, NXF5, TAPL1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Could be involved in the export of mRNA from the nucleus to the cytoplasm. Could also have a role in polarized cytoplasmic transport and localization of mRNA in neurons.|
|Cellular Location||Cytoplasm. Nucleus. Note=Mainly localized in the cytoplasm of cells and more particularly in the cell body and neurites of hippocampal neurons. Although nuclear localization is also observed. Not detected at nuclear rim|
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This gene is one member of a family of nuclear RNA exportfactor genes. The encoded protein can bind RNA, and is implicatedin mRNA nuclear export. However, this protein has lost severalC-terminal protein domains found in other family members that arerequired for export activity, and may be an evolving pseudogene.Alternatively spliced transcript variants have been described, butmost are candidates for nonsense-mediated decay (NMD) and may notexpress proteins in vivo.
Tarpey, P.S., et al. Nat. Genet. 41(5):535-543(2009)Hillman, R.T., et al. Genome Biol. 5 (2), R8 (2004) :Frints, S.G., et al. Am. J. Med. Genet. A 119A (3), 367-374 (2003) :Jun, L., et al. Curr. Biol. 11(18):1381-1391(2001)Herold, A., et al. Mol. Cell. Biol. 20(23):8996-9008(2000)
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