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NXF5 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9H1B4 |
|---|---|
| Clone Names | 110811143 |
| Other Names | Nuclear RNA export factor 5, TAP-like protein 1, TAPL-1, NXF5, TAPL1 |
|---|---|
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | NXF5 |
|---|---|
| Synonyms | TAPL1 |
| Function | Could be involved in the export of mRNA from the nucleus to the cytoplasm. Could also have a role in polarized cytoplasmic transport and localization of mRNA in neurons. |
| Cellular Location | Cytoplasm. Nucleus. Note=Mainly localized in the cytoplasm of cells and more particularly in the cell body and neurites of hippocampal neurons. Although nuclear localization is also observed Not detected at nuclear rim |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene is one member of a family of nuclear RNA exportfactor genes. The encoded protein can bind RNA, and is implicatedin mRNA nuclear export. However, this protein has lost severalC-terminal protein domains found in other family members that arerequired for export activity, and may be an evolving pseudogene.Alternatively spliced transcript variants have been described, butmost are candidates for nonsense-mediated decay (NMD) and may notexpress proteins in vivo.
References
Tarpey, P.S., et al. Nat. Genet. 41(5):535-543(2009)Hillman, R.T., et al. Genome Biol. 5 (2), R8 (2004) :Frints, S.G., et al. Am. J. Med. Genet. A 119A (3), 367-374 (2003) :Jun, L., et al. Curr. Biol. 11(18):1381-1391(2001)Herold, A., et al. Mol. Cell. Biol. 20(23):8996-9008(2000)
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